Mechanism of Action

BAXDELA® (delafloxacin) Mechanism of Action

MOLECULAR ENGINEERING HAS LED TO THE CREATION OF BAXDELA

  • Anionic in nature
  • Antibacterial activity is due to the inhibition of topoisomerase IV and DNA gyrase
    • Similar affinity for both enzymes1,2
  • Complex pathway required for resistance
    • In vitro resistance to BAXDELA developed by multiple step mutations in the quinolone-resistance determining regions of gram-positive and gram-negative bacteria. BAXDELA-resistant mutants were selected in vitro at a frequency of <10-9
  • Cross-resistance between BAXDELA and other fluoroquinolones has been observed. However, some isolates resistant to other fluoroquinolones may be susceptible to BAXDELA

1. Van Bambeke F. Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy. Future Microbiol. 2015;10(7):1111-1123. doi:10.2217/fmb.15.39
2. Jorgensen SCJ, Mercuro NJ, Davis SL, Rybak MJ. Delafloxacin: place in therapy and review of microbiologic, clinical and pharmacologic properties. Infect Dis Ther. 2018;7(2):197-217. doi:10.1007/s40121‑018‑0198‑x

 

INDICATION & USAGE:

BAXDELA is indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by the following susceptible microorganisms: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, and Enterococcus faecalis, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

BAXDELA® is indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP) caused by designated susceptible bacteria.